Syntheses ofN-Acyl Dipeptide Derivatives by Metalloproteinases

Activation of mouse peritoneal adherent cells with N-acyl muramyl dipeptide derivatives.

The effect of N-acyl derivatives of muramyl dipeptide (N-acetyl muramyl-L-alanyl-D-isoglutamine) on the activation of peritoneal adherent cells (PAC) in vivo and on the stimulation of nonspecific host resistance against Escherichia coli infection was examined in comparison with the effect of 6-O-stearoyl muramyl dipeptide. N-acyl muramyl dipeptide derivatives increased the release of hydrogen p...

Syntheses of Anisomycin Derivatives

The structure of anisomycin has been determined by X-ray investigation4 and the absolute configuration was confirmed by chemical correlation.5 Anisomycin has attracted considerable synthetic interest, and several synthetic studies, derivative syntheses as well as total syntheses, have been reported.6 Especially, the synthesis of its analogues has revealed the structure-activity relationship of ...

Syntheses and biological evaluation of 2-amino-3-acyl-tetrahydrobenzothiophene derivatives; antibacterial agents with antivirulence activity.

Developing new compounds targeting virulence factors (e.g., inhibition of pilus assembly by pilicides) is a promising approach to combating bacterial infection. A high-throughput screening campaign of a library of 17 500 small molecules identified 2-amino-3-acyl-tetrahydrobenzothiophene derivatives (hits 2 and 3) as novel inhibitors of pili-dependent biofilm formation in a uropathogenic Escheri...

Syntheses and antimicrobial activities of 9-O-acyl derivatives of tylosin and demycarosyltylosin.

Muramyl Dipeptide (MDP) Derivatives: Dendritic Cell Maturation Induced by